Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI. Inhibitory Effects of Caffeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

Abstract

The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5×10^-5M, caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3, 5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10^-5M.