Syntheses of Apogalanthamine Analogs as α-Adrenergic Blocking Agents. VIII. Syntheses of 4- and 9-Bromo-5, 6, 7, 8-tetrahydrodibenz [c, e] azocines and Their Methylenedioxy Derivatives

抄録

The apogalanthamine analogs 4- and 9-bromo-5, 6, 7, 8-tetrahydrodibenz [c, e] azocines (5a and 6a) and their methylenedioxy derivatives (5b and 6b) were prepared by photolysis of the hydrochlorides of the respective N-benzyl-β-phenethylamines (8a, b and 9a, b) substituted with both iodine and bromine atoms. The dibenz [c, e] azocines 6a and 6b were also obtained by thermal syntheses from the biphenyl compounds 17a and 17b, respectively.