Studies on Aromatic Nitro Compounds. V. A Simple One-Pot Preparation of o-Aminoaroylnitriles from Some Aromatic Nitro Compounds

Abstract

The reactions of 3-, 5-, 6-, 7- and 8-nitroquinolines, 1-or 2-nitronaphthalene and m-substituted (CF₃, COCH₃ and COC₆H₅) nitrobenzenes with ethyl cyanoacetate and potassium hydroxide in dimethylformamide, followed by hydrolysis of the reaction mixture with hydrochloric acid or sodium hydroxide, gave the corresponding o-aminoaroylnitriles.