Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Aromatic Nitro Compounds. V. A Simple One-Pot Preparation of o-Aminoaroylnitriles from Some Aromatic Nitro Compounds
YUKIHIKO TOMIOKAKIMIKO OHKUBOMOTOYOSHI YAMAZAKI
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1985 Volume 33 Issue 4 Pages 1360-1366

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Abstract

The reactions of 3-, 5-, 6-, 7- and 8-nitroquinolines, 1-or 2-nitronaphthalene and m-substituted (CF3, COCH3 and COC6H5) nitrobenzenes with ethyl cyanoacetate and potassium hydroxide in dimethylformamide, followed by hydrolysis of the reaction mixture with hydrochloric acid or sodium hydroxide, gave the corresponding o-aminoaroylnitriles.

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© The Pharmaceutical Society of Japan
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