Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A Simple Synthesis of 1, 3-Dialkylpyrido [2, 3-d] pyrimidines
TSUNEO ITOHTOSHIHIKO IMINIHARUO OGURANORIO KAWAHARATAKAKO NAKAJIMAKYOICHI A. WATANABE
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1985 Volume 33 Issue 4 Pages 1375-1379

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Abstract

A new and convenient synthesis of 1, 3-dialkylpyrido [2, 3-d] pyrimidine-2, 4 (1H, 3H)-diones from 6-allylamino-and 6-(substituted allyl) aminouracils by PdCl2-CuCl-O2-catalyzed oxidative cyclization is described. Further, 1, 3-dimethylpyrido [2, 3-d] pyrimidine 2, 4 (1H, 3H)-dione (4a) was prepared by the reaction of 6-allylamino-1, 3-dimethyluracils (3a) with (AcO)2 Pd and by the thermal cyclization of 3a.

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