1985 Volume 33 Issue 4 Pages 1499-1502
The anticoagulative principles were isolated from Curcumae Rhizoma by a combination of partition and column chromatographies on silica gel, and identified as 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione (curcumin), p, p'-dihydroxydicinnamoylmethane and p-hydroxycinnamoylferuloylmethane. During the isolation process plasma recalcification time in mice was used to follow the anticoagulative activity of the material.