Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Enzymic Formation of β-Alkyl Glycosides by β-Galactosidase from Aspergillus oryzae and Its Application to the Synthesis of Chemically Unstable Cardiac Glycosides
YASUHIRO OOITOSHIHIRO HASHIMOTONAOKI MITSUOTOSHIO SATOH
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Keywords: alkyl β-glycoside
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1985 Volume 33 Issue 5 Pages 1808-1814

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Abstract

β-Galactosidase obtained from Aspergillus oryzae was found to have strong transglycosylation activity. The glycosylation of water-soluble and insoluble alcohols was successfully performed under mild conditions (pH 5 at 4-37°C) with this enzyme. The enzyme was also applied to the onestep synthesis of several cardiac glycosides that are diffcult to obtain by ordinary chemical methods.

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© The Pharmaceutical Society of Japan
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