Enantioselective Synthesis of Peptides Using (1R)-3-Hydroxy-1, 8, 8-trimethyl-3-azabicyclo [3. 2. 1] octane-2, 4-dione ((+)-N-Hydroxycamphorimide) an Active Ester Group

Abstract

The enantioselective coupling reaction of N-protected amino acid (+)-N-hydroxycamphorimide esters (-OCamp) with racemic amino acid esters is discussed. The coupling reaction of several amino acids showed high enantioselectivity.