COMPLEX FORMATION BETWEEN DI-AND MONOPHOSPHATIDYLCHOLINES AND CYCLODEXTRINS IN WATER

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α-, β- and γ-Cyclodextrins (CDs) interact with phospholipid membranes causing an appreciable decrease in the surface pressure of monolayer films of dimyristoylphosphatidylcholine and a leakage of the marker, calcein, in the inner aqueous phase of a liposome which is composed of diacylphosphatidylcholine (DAPC) and dicetylphosphate. The α- and γ-CDs form white amorphous solids with DAPC in the unilamellar state in aqueous solutions. These solids consist of CD and DAPC. The molar ratio of CD to DAPC depends on the kinds of CD and the acyl chain length of DAPC. From the composition of the CD-DAPC complex, several molecules of CD include two acyl chains of DAPC to make complexes such as alkanoic acid-CD complexes.