Uptake of Li⁺ by Ehrlich Ascites Tumor Cells Induced by Neutral Amino Acids

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Uptake of Li⁺ by Ehrlich ascites tumor cells induced by amino acid influx was measured with an Li⁺-selective electrode. Alanine and serine induced the largest influxes of Li⁺, while cysteine, glycine, α-aminoisobutyric acid, proline and threonine elicited Li⁺ uptake to lesser extents. These amino acids also induced Na⁺ uptake. It seems that the A system is responsible for Li⁺-amino acid cotransport. Some kinetic properties of the Li⁺ uptake were investigated.