Stereoselective Reactions. IX. Synthetic Studies on Optically Active β-Lactams. I. Chiral Synthesis of Carbapenam and Carbapenem Ring Systems Starting from (S)-Aspartic Acid

抄録

A chiral carbapenam ring system ((3R, 5R)-(+)-19 and -20) having the desired absolute configuration at C-5 was synthesized starting from (S)-aspartic acid, and the latter product was further transformed to a chiral carbapenem derivative ((5S, 2'R)-(+)-21) having an (R)-cysteine moiety as a side chain.