Cyclic Guanidines. XVI. Synthesis and Biological Activities of Tetracyclic Imidazo [2, 1-b] quinazolinone Derivatives

FUMIYOSHI ISHIKAWA; HITOSHI YAMAGUCHI; JUNJI SAEGUSA; KAZUE INAMURA; TETSUYA MIMURA; TOSHIYUKI NISHI; KYOKO SAKUMA; SHINICHIRO ASHIDA

doi:10.1248/cpb.33.3336

FUMIYOSHI ISHIKAWA, HITOSHI YAMAGUCHI, JUNJI SAEGUSA, KAZUE INAMURA, TETSUYA MIMURA, TOSHIYUKI NISHI, KYOKO SAKUMA, SHINICHIRO ASHIDA

Author information

Keywords: structure-activity relationship

JOURNAL FREE ACCESS

1985 Volume 33 Issue 8 Pages 3336-3348

DOI https://doi.org/10.1248/cpb.33.3336

Details

Abstract

Tetracyclic imidazo [2, 1-b] quinazolinone derivatives (18) with a modified or unmodified alkylene chain were prepared and evaluated for their ability to inhibit platelet aggregation. Most of the compounds were very potent except for some compounds substituted with an amino or a hydroxy group. The structure-activity relationships are discussed.

Corresponding author

Register with J-STAGE for free!