Abstract
N3-Benzyluridine (I), a derivative of uracil (II) or uridine (III), has hypnotic effect on mice. The hypnotic effect of I was effected by intracerebroventricular injection. The response was dose-dependent with doses of 1.5-4.0 μmol/mouse. Further, I significantly prolonged pentobarbital-induced sleep in mice. In the same doses, II and III have no hypnotic or sleep-prolonging effects. These results suggest that III may be a sleep-promoting substance basically, as reported by Komoda et al.
