Abstract
Although rate fed on a high-protein diet of 70% casein showed hyperazotemia, administration of the extract from Rhei Rhizoma induced decreases of blood urea nitrogen, ammonia nitrogen in the portal vein, urea concentration in hepatic tissue, and Gln, Lys, Thr, Ala, Gly, Ser, Glu, Pro, Arg, Tyr, Cit, Asp, etc. in serum, while significant increases of Glu and Asp in hepatic tissue were observed. The modification of the nitrogen-processing mechanism by rhubarb extract is discussed on the basis of the present results.
