抄録
(±)-2, 4, 5- and 2, 4, 8-Trihydroxy-1-tetralones (2, 9, 3, 11) were synthesized from juglone, and their cytotoxic activities against Yoshida sarcoma cells were examined. The trihydroxytetralones were more cytotoxic than dihydroxytetralones. While the configuration of the hydroxyl groups in the alicyclic ring scarcely affected the cytotoxicity against Yoshida sarcoma cells, the position of the hydroxyl groups in the aromatic ring seem to be important. The 2, 4, 8-trihydroxytetralones (3, 11) were more cytotoxic than the 2, 4, 5-trihydroxy derivatives (2, 9).
