Synthesis of Deacetyl-thymosin β₁₀ and Examination of Its Immunological Effect on T-Cell Subpopulations of a Uremic Patient with Tuberculosis

抄録

Deacetyl-thymosin β₁₀ was synthesized by a conventional solution method, by assembling seven peptide fragments followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The synthetic deacetyl-thymosin β₁₀ increased the entire peripheral T-cell population and a helper T-cell subset when incubated in vitro with blood obtained from a uremic patient with tuberculosis, but a suppressor/cytotoxic T-cell subset was unaffected under these conditions.