Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)

NOBUTAKA FUJII; AKIRA OTAKA; SUSUMU FUNAKOSHI; MOTOYOSHI NOMIZU; KENICHI AKAJI; HARUAKI YAJIMA; KOUKI KITAGAWA; TADASHI AKITA; KENSHI ANDO; TATSUHIKO KAWAMOTO

doi:10.1248/cpb.34.603

Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)

NOBUTAKA FUJII, AKIRA OTAKA, SUSUMU FUNAKOSHI, MOTOYOSHI NOMIZU, KENICHI AKAJI, HARUAKI YAJIMA, KOUKI KITAGAWA, TADASHI AKITA, KENSHI ANDO, TATSUHIKO KAWAMOTO

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Keywords: N^G-mesitylenesulfonylarginine

JOURNAL FREE ACCESS

1986 Volume 34 Issue 2 Pages 603-612

DOI https://doi.org/10.1248/cpb.34.603

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Abstract

Seven peptide fragments were synthesized by known amide-forming reactions as building blocks for the solution-phase synthesis of the heptatriacontapeptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP). S-1-Adamantyl-cysteine [O. Nishimura, C. Kitada, and M. Fujino, Chem. Pharm. Bull., 26, 1576 (1978)] was employed, together with amino acid derivatives bearing protecting groups removable by 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid.

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