The Chemistry of Indoles. XXVII. : A Practical Synthesis of the 1-Methoxy Analog of an Ergot Alkaloid, (±)-1-Methoxy-6, 7-secoagroclavine

MASANORI SOMEI; HIROYUKI OHNISHI; YUKA SHOKEN

doi:10.1248/cpb.34.677

MASANORI SOMEI, HIROYUKI OHNISHI, YUKA SHOKEN

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Keywords: 4, 5-trans-1-methoxy-5-(2-methyl-1-propenyl)-4-nitro-1, 3, 4, 5-tetrahydrobenz[cd]indole

JOURNAL FREE ACCESS

1986 Volume 34 Issue 2 Pages 677-681

DOI https://doi.org/10.1248/cpb.34.677

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Abstract

The first syntheses of 1-methoxy analogs of ergot alkaloids, (±)-1-methoxy-6, 7-secoagroclavine and (±)1-methoxy-6-nor-6, 7-secoagroclavine, were achieved with good overall yield in only nine steps from 2-nitrotoluene.

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