Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. I
キーワード:
1, 5-benzoxazepine
1986 年 34 巻 3 号 p. 1128-1147
詳細
1986 年 34 巻 3 号 p. 1128-1147
The design and synthesis of new structural types of angiotensin converting enzyme (ACE) inhibitors, (R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5-acetic acids (7, 26, 33 and 37) and (S)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine-5-acetic acids (8 and 27), are described. A number of compounds in these series showed potent ACE inhibitory activity in vitro and in vivo. The structure-activity relationship is also discussed.
