ACID-CATALYZED EPIMERIZATION OF 2-DEOXY-2-FLUORO-D-HEXOSES

Terushi Haradahira; Minoru Maeda; Yoko Kanazawa; Yuko Momozono; Masaharu Kojima

doi:10.1248/cpb.34.1407

Terushi Haradahira, Minoru Maeda, Yoko Kanazawa, Yuko Momozono, Masaharu Kojima

Author information

Keywords: ^<19>F-NMR

JOURNAL FREE ACCESS

1986 Volume 34 Issue 3 Pages 1407-1410

DOI https://doi.org/10.1248/cpb.34.1407

Details

Abstract

Interconversion of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-2-fluoro-D-mannose (FDM) catalyzed by acid has been detected by ¹⁹F-NMR method. Although FDG and FDM were stable towards 1 N hydrochloric acid, in stronger acidic media the two hexoses underwent epimerization at C-2.

Corresponding author

Register with J-STAGE for free!