Author's Organization：Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo Faculty of Pharmaceutical Sciences, Science University of Tokyo
Acid treatment of o-quinol acetates (2a and 2b) derived from 5-hydroxy-1-benzyltetrahydroisoquinolines (3a and 3b) gave the corresponding 3-hydroxyaporphines (4a and 4b) in high yield.Similarly, the 3-hydroxyhomoaporphines (4c, 4d, and 4e) were excusively synthesized from the corresponding 1-phenethyl o-quinol acetates (2c, 2d, and 2e). On the other hand, no C-noraporphine was formed from the 1-aryl o-quinol acetate (2f); instead, the p-quinone (11) was generated.
