DIFFERENTIATION INDUCERS OF HUMAN PROMYELOCYTIC LEUKEMIA CELLS HL-60.PHENYLCARBAMOYLBENZOIC ACIDS AND POLYENE AMIDES

Abstract

New inducers of the differentiation of human promyelocytic leukemia cells HL-60 to mature granulocytes, 4-(3, 4-diisopropylphenylcarbamoyl)benzoic acid (2c) and 4-(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethylnaphthyl-2-carbamoyl)benzoic acid (2d), have been found. Two polyene amides which are structural hybrids of retinoic acid and the amide compounds 1a and 2d also exhibited the biological activity, and this result suggested a structural link between retinoic acid and the active aromatic amides.