Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis and Properties of 2', 5'-Adenylate Trimers Bearing 2'-Terminal 8-Bromo- or 8-Hydroxyadenosine
SHIRO YOSHIDA, HIROSHI TAKAKU
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Keywords: reversed-phase liquid chromatography
JOURNAL FREE ACCESS

1986 Volume 34 Issue 6 Pages 2456-2461

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Abstract
Trimers of 2', 5'-oligoadenylic acids bearing 2'-terminal 8-bromo- or 8-hydroxyadenosine have been synthesized by the phosphotriester method. Some properties of these compounds were studied by circular dichroism (CD) spectroscopy. The 2', 5'-adenylate trimer, A2'p5'A2'p5'HOA (10a) was found to have a less stacked structure than the 2', 5'-adenylate trimers A2'p5'A2'p5'BrA (11) and A2'p5'A2'p5'A (10b).
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© The Pharmaceutical Society of Japan
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