Anti-inflammatory Constituents of Topically Applied Crude Drugs. I. : Constituents and Anti-inflammatory Effect of Eriobotrya japonica LINDL.

MINEO SHIMIZU; HIDEKI FUKUMURA; HIDEKI TSUJI; SEIICHI TANAAMI; TOSHIMITSU HAYASHI; NAOKATA MORITA

doi:10.1248/cpb.34.2614

MINEO SHIMIZU, HIDEKI FUKUMURA, HIDEKI TSUJI, SEIICHI TANAAMI, TOSHIMITSU HAYASHI, NAOKATA MORITA

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Keywords: histamine-induced contraction

JOURNAL FREE ACCESS

1986 Volume 34 Issue 6 Pages 2614-2617

DOI https://doi.org/10.1248/cpb.34.2614

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Abstract

The ether-soluble fraction of EtOH extract from the leaves of Eriobotrya japonica LINDL.showed an anti-inflammatory effect when topically applied to rats. Ursolic acid, maslinic acid, methyl maslimate and euscaphic acid were isolated from the ether-soluble fraction. Maslinic acid was found to show an anti-inflammatory effect on carrageenan-induced edema and an inhibitory effect on histamine-induced ileum contraction.

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