Prolonged Blood Concentration of Salicylic Acid Following the Simultaneous Oral Administration of Salicylic Acid and Salicyluric Acid in Rabbits

Abstract

Salicylic acid was detected in the blood at 2h after oral administration of salicyluric acid(60 mg/kg : salicylic acid equivalent) to rabbits and reached the maximum level at 5h (about 9.7 μg/ml). The levels of salicylic acid remained above 7μg/ml for several hours, after which they slowly declined. Following the simultaneous oral administration of salicylic acid (7.5 mg/kg) and salicyluric acid (60 mg/kg : salicylic acid equivalent), the blood concentration of salicylic acid was maintained at 8.5-15.3μg/ml from 6 min to 12h. Different blood level patterns of salicylic acid could be produced by simultaneous oral administration of salicyluric acid and various doses of salicylic acid.