Effect of 6-(10-Hydroxydecyl)-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (CV-2619) on Microsomal Lipid Peroxidation

抄録

6-(10-Hydroxydecyl)-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (CV-2619) and related compounds (the corresponding hydroquinone and hydroquinone monosulfate forms) inhibited lipid peroxidation, especially that initiated with ferrous ion in microsomes of rat liver and canine brain. The fact that CV-2619 inhibited the Fe²⁺ -dependent peroxidation of the membrane lipid in microsomes and linolenic acid indicated that CV-2619 itself possesses antioxidant activity, like its hydroquinone form. However, CV-2619 barely inhibited lipid peroxidation in aged membranes and did not quench hydroxy radicals. It showed some stimulation of peroxide quenching systems, such as horserdish peroxidase and rat liver cytosomal peroxidation-inhibiting protein. These results suggest that CV-2619 mainly inhibits the initial steps of lipid peroxidation.