Automated System of Dissolution Testing with Data Input through RS-232C Interface of a Personal Computer

抄録

An automated system for in vitro drug dissolution testing was developed around the PC-9801 or PC-8801 series of personal computers. The hardware consists of the standard dissolution vessel, a ultravioled (UV) detector, an intelligent A/D converter and a personal computer which is connected with an XY-plotter. The fluid in the dissolution vessel is recirculated between the vessel and the UV detector by a pump through fine polyethylene tubing. The signals from the A/D converter, which is connected with the UV detector, are taken into the personal computer through the RS-232C interface. A program (Automated Dissolution Measurement Program ADMP) was written in BASIC to control the A/D converter, to store the dissolution data on floppy disk, to plot the time course of dissolution on CRT and XY-plotter, and to calculate the dissolution parameters, such as the 50% dissolution time (t₅₀) and the mean dissolution time (MDT).