Polycyclic N-Hetero Compounds. XXIII. : Synthesis and Antidepressive Activity of 4-Substituted 5, 6-Dihydrobenzo[h]quinazolines

Abstract

4-Alkylamino-5, 6-dihydrobenzo[h]quinazolines (IIIa-k) were synthesized by the reaction of 4-chloro-5, 6-dihydrobenzo[h]quinazoline (IIc) with primary alkylamines. Screening of 4-amino-(IIa), 4-hydroxy-(IIb), and 4-(2-hydroxyethylamino)-5, 6-dihydrobenzo[h]quinazoline (IId), as well as IIc and IIIa-k, for antireserpine action indicated that IId, IIIa, and IIIh exhibited effective antidepressant activity.