抄録
Total synthesis of (-)-antirhine (5) has been achieved from a potentially useful chiral synthon, (3R)-[3-hydroxy-(E)-prop-1-enyl]cyclopentanone (2) [derived from (R)-1, 2-isopropylideneglyceraldehyde (1)], via the β, γ-unsaturated aldehyde (12), which was obtained by mild hydrolysis of the α-cyano-N, N-dimethylaminocyclopentanone (11).
