Studies on Syntheses and Reactions of Methoxypyridazines. II. Methoxylation of 3, 4, 6-Trichloropyridazine

Abstract

Methoxylation of 3, 4, 6-trichloropyridazine (1) with sodium methoxide was investigated in detail. Dimethoxylation of 1 afforded 6-chloro-3, 4-dimethoxypyridazine (5) and a molecular complex (M) which is composed of 5 and 3-chloro-4, 6-dimethoxypyridazine (6) in a ratio of 1 : 1. The nature of the complex (M) was examined by thermal and X-ray analyses. The molecular complex (M) was also obtained by monomethoxylation of 3, 6-dichloro-4-methoxypyridazine (3) with sodium methoxide.