抄録
Mefloquine enantiomers (+) -1, (-) -1 were found to be stereospecific in their inhibition of acetylcholinesterase and butyrylcholinesterase, (-) -1 being the more potent inhibitor in both cases. Similar observations were also made with respect to (-) -quinine and (+) -quinidine, which are configurational analogues of (+) -1 and (-) -1, respectively. A positive synclinical conformation for the “N-C-C-O” segment of mefloquine appeared to be necessary for good activity.
