Preparation of 3-Aminonocardicinic Acid and Its Acyl Derivatives

OSAMU NAKAGUCHI; TERUO OKU; MASASHI HASHIMOTO; TAKASHI KAMIYA

doi:10.1248/cpb.35.3979

OSAMU NAKAGUCHI, TERUO OKU, MASASHI HASHIMOTO, TAKASHI KAMIYA

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Keywords: 3-aminonocardicinic acid, nocardicin, antibacterial activity, structure-activity relationship, the Edman degradation

JOURNAL FREE ACCESS

1987 Volume 35 Issue 10 Pages 3979-3984

DOI https://doi.org/10.1248/cpb.35.3979

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Abstract

3-Aminonocardicinic acid (3-ANA, 2) was prepared by removal of the N-acyl group of nocardicin A (1). Reacylation of 2 with some typical side-chain acids gave the corresponding semisynthetic nocardicins 6.

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