Synthesis of Some Polyhydroxylated Pyrrolidine Derivatives

HIROYUKI SETOI; HIROSHI KAYAKIRI; HIDEKAZU TAKENO; MASASHI HASHIMOTO

doi:10.1248/cpb.35.3995

HIROYUKI SETOI, HIROSHI KAYAKIRI, HIDEKAZU TAKENO, MASASHI HASHIMOTO

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Keywords: swainsonine, azamannofuranose, enantiospecific synthesis, D-mannose, immunostimulating activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 10 Pages 3995-3999

DOI https://doi.org/10.1248/cpb.35.3995

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Abstract

Polyhydroxylated pyrrolidine derivatives, 7, 11, 15, and 18, were synthesized from 4, a. key intermediate for our total synthesis of swainsonine (1). The immunostimulating activities of these new derivatives were found to be moderate and less than that of swainsonine.

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