Synthesis of 5-Carbon-Substituted 1-β-D-Ribofuranosylimidazole-4-carboxamides via Lithiation of a Primary Carboxamide

MASAHIRO SUZUKI; HIROMICHI TANAKA; TADASHI MIYASAKA

doi:10.1248/cpb.35.4056

Synthesis of 5-Carbon-Substituted 1-β-D-Ribofuranosylimidazole-4-carboxamides via Lithiation of a Primary Carboxamide

MASAHIRO SUZUKI, HIROMICHI TANAKA, TADASHI MIYASAKA

著者情報

キーワード: lithiation, imidazole nucleoside, 5-substituted 1-β-D-ribofuranosylimidazole-4-carboxamide, lithium diisopropylamide, lithium 2, 2, 6, 6-tetramethylpiperidide, Wittig reaction

ジャーナルフリー

1987 年 35 巻 10 号 p. 4056-4063

DOI https://doi.org/10.1248/cpb.35.4056

詳細

抄録

Several 5-carbon-substituted 1-β-D-ribofuranosylimidazole-4-carboxamides were synthesized via the direct C-5 lithiation of a protected 4-carboxamide derivative as the key reaction step. Wittig reaction of a 5-formyl derivative was also examined.

責任著者(Corresponding author)

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