Lipid A and Related Compounds. XVI. Synthesis of Biologically Active Tetraacetyl-3-deoxy-D-manno-2-octulosonic Acid (KDO) - (α2→6) -D-Glucosamine-4-phosphates, Novel Analogs of the Nonreducing Sugar Moiety of Lipid A

SHIN-ICHI NAKAMOTO; KAZUO ACHIWA

doi:10.1248/cpb.35.4537

Lipid A and Related Compounds. XVI. Synthesis of Biologically Active Tetraacetyl-3-deoxy-D-manno-2-octulosonic Acid (KDO) - (α2→6) -D-Glucosamine-4-phosphates, Novel Analogs of the Nonreducing Sugar Moiety of Lipid A

SHIN-ICHI NAKAMOTO, KAZUO ACHIWA

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Keywords: lipid A analog, KDO-linked glucosamine, 4-phosphorylated glucosamine, mitogenic activity, antitumor activity, lethal toxicity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 11 Pages 4537-4543

DOI https://doi.org/10.1248/cpb.35.4537

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Abstract

Synthesis of biologically active tetraacetyl-3-deoxy-D-manno-2-octulosonic acid- (α2→6) -D-glucosamine-4-phosphate analogs of lipid A is described.

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