Inhibitory Effect of Bis [2- (E-2-alkenoylamino) ethyl] Disulfides and 2- (E-Octenoylamino) ethyl Carbamoylmethyl Sulfides on Carrageenin-Induced Paw Edema in Rats

Abstract

Two series of bis [2- (E-2-alkenoylamino) ethyl] disulfides (compds. I) and 2- (E-alkenoyl-amino) ethyl carbamoylmethyl sulfides (compds. II) were synthesized from 2-trans unsaturated fatty acids (C_{6 : 1}-C_{14 : 1}) and cystamine, and their effects on carrageenin-induced paw edema were studied. Several of compds. I and II showed significant anti-edema activity at a dose of 25 mg/kg, i. p. These derivatives were much more potent than the starting materials. The alkene chain length influenced the activity. The compounds (compds. I-3, I-8, II-3 and II-8) with C_{8 : 1} and C_{13 : 1} fatty acids showed the highest activity in both series. Compounds I-3 and II-3 with the C_{8 : 1} fatty acid were also effective when administered orally at a dose of 10 mg/kg.