Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenylmethylpiperazine Derivatives

Abstract

1-Benzyl-4-diphenylmethylpiperidine derivatives were prepared to investigate the role of the nitrogen atom in their cerebral vasodilating activity. The pharmacological test results revealed that the piperidine derivatives are roughly equipotent to the piperazine derivatives in our test system. Structure-activity analyses are presented.