Synthetic Studies of (±) -Lysergic Acid and Related Compounds

TAKUSHI KURIHARA; TATSUYA TERADA; SHINYA HARUSAWA; RYUJI YONEDA

doi:10.1248/cpb.35.4793

TAKUSHI KURIHARA, TATSUYA TERADA, SHINYA HARUSAWA, RYUJI YONEDA

Author information

Keywords: (±) -lysergic acid, Uhle's ketone, benz [cd] indole-5-carbaldehyde, ethyl 3-aminopropionate, lithium diisopropylamide, indolo [3, 4, 5-gh] isoquinoline, 1, 8-diazabicyclo [5.4.0] -7-undecene, mesyl chloride, 2D-NMR, NOE

JOURNAL FREE ACCESS

1987 Volume 35 Issue 12 Pages 4793-4802

DOI https://doi.org/10.1248/cpb.35.4793

Details

Abstract

A new and simple method for a formal synthesis of (±) -lysergic acid (1), via a four-step sequence starting from the aldehyde (13), is described. A very high yield of the product was obtained after purification by column chromatography at the end of the process, without isolation of intermediates.

Corresponding author

Register with J-STAGE for free!