Amino Acids and Peptides. XIV. Synthesis and Biological Activity of Three S-Peptide Analogues of Bovine Pancreatic Ribonuclease A (RNase A)

NAOKI TENO; SATOSHI TSUBOI; TOMOKO SHIMAMURA; YOSHIO OKADA; YOSHIMI YANAGIDA; MAKIKO YOSHINAGA; KAZUKO OHGI; MASACHIKA IRIE

doi:10.1248/cpb.35.468

NAOKI TENO, SATOSHI TSUBOI, TOMOKO SHIMAMURA, YOSHIO OKADA, YOSHIMI YANAGIDA, MAKIKO YOSHINAGA, KAZUKO OHGI, MASACHIKA IRIE

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Keywords: bovine pancreatic ribonuclease A, S-peptide, [Lys¹] [Lys⁷] S-peptide analogue, chemical synthesis, reactivation ability, structure-activity relationship, succinimide formation, active ester coupling

JOURNAL FREE ACCESS

1987 Volume 35 Issue 2 Pages 468-478

DOI https://doi.org/10.1248/cpb.35.468

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Abstract

Three S-peptide analogues of bovine pancreatic ribonuclease A (RNase A), [Nle¹] [Lys⁷] S-peptide (I), [Lys¹] [Nle⁷] S-peptide (II) and [Nle¹] [Nle⁷] S-peptide (III), were synthesized by the fragment condensation method and their ability to reactivate S-protein was examined. It was found that Lys¹ and Lys⁷ both have roles in the reactivation of S-protein.

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