Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
One-Pot Synthesis of N-Alkylpyrrolidines by 1, 3-Dipolar Cycloaddition
NOBUYUKI IMAI, KAZUO ACHIWA
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Keywords: 1, 3-dipolar cycloaddition, N-alkylpyrrolidine, N-unsubstituted pyrrolidine, N-alkylazomethine ylide, N-trimethylsilylazomethine ylide, N- (benzylidene) trimethylsilylmethylamine, Schiff base
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1987 Volume 35 Issue 2 Pages 593-601

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Abstract
N-Alkylpyrrolidines were obtained by one-pot synthesis through 1, 3-dipolar cycloaddition of the N-alkylazomethine ylide intermediates generated from N- (benzylidene) trimethylsilylmethylamine and alkyl halide or tosylate.
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© The Pharmaceutical Society of Japan
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