Synthesis and Hypotensive Activity of Benzopyran Derivatives

MASAMI SHIRATSUCHI; KIYOSHI KAWAMURA; TOSHIHIRO AKASHI; MIKIO FUJII; HIROSHI ISHIHAMA; YASUMI UCHIDA

doi:10.1248/cpb.35.632

MASAMI SHIRATSUCHI, KIYOSHI KAWAMURA, TOSHIHIRO AKASHI, MIKIO FUJII, HIROSHI ISHIHAMA, YASUMI UCHIDA

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Keywords: β-adrenergic blocking activity, vasodilating activity, antihypertensive drug, dihydrobenzopyran, nitrate, nipradilol

JOURNAL FREE ACCESS

1987 Volume 35 Issue 2 Pages 632-641

DOI https://doi.org/10.1248/cpb.35.632

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Abstract

A series of dihydrobenzopyranyloxypropanolamines and dihydrobenzopyranylethanolamines containing a nitroxy moiety was synthesized. The cardiovascular effects of these compounds were investigated in anesthetized dogs. Some of the compounds exhibited hypotensive activity in combination with β-adrenergic blocking and vasodilating action. The structure-activity relationships are discussed.

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