Hydrogen Fluoride Adduct Formation of Medicinal Compounds and Its Application to Particle Size Reduction

Abstract

It was confirmed that griseofulvin, sulfanilamide and theophylline form HF adducts with combining ratios of 1 : 1 (griseofulvin : HF), 1 : 2 (sulfanilamide : HF) and 1 : 3 and 1 : 2 (theophylline : HF). The thermal and other physico-chemical properties of these adducts and the recovered medicinals were investigated by differential scanning calorimetry, thermogravimetry, X-ray powder diffractometry, infrared spectroscopy and microscopy. Effective particle size reduction was achieved by desorbing HF from the adducts.