Macromolecular Complexes of Drugs. I. Doxorubicin-Heparin Complex

TOSHINOBU AOYAMA; MASAYOSHI HORIOKA; SHINGO NAGAMITSU

doi:10.1248/cpb.35.808

TOSHINOBU AOYAMA, MASAYOSHI HORIOKA, SHINGO NAGAMITSU

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Keywords: complex, heparin, doxorubicin, anticancer drug, macromolecular complex, particle count, energy dispersing X-ray

JOURNAL FREE ACCESS

1987 Volume 35 Issue 2 Pages 808-813

DOI https://doi.org/10.1248/cpb.35.808

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Abstract

As a part of our studies to develop anticancer agents with prolonged action and reduced side effects, we examined the macromolecular complex of doxorubicin and heparin. Formation of a complex of doxorubicin and heparin was confirmed by HIAC, infrared, ultraviolet, differential scanning calorimetry, energy micro analysis X-ray and high performance liquid chromatography analysis. If the molecular weight of heparin is assumed to be 9800, one molecule of heparin binds 16 molecules of doxorubicin.

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