THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF 3, 3'-DIHYDROXY-α, β-DIETHYLSTILBENE

Yoshihiko Inamori; Mayuri Kubo; Hiroshi Tsujibo; Masafumi Ogawa; Yoshinobu Saito; Yasuyoshi Miki; Shoji Takemura

doi:10.1248/cpb.35.887

Yoshihiko Inamori, Mayuri Kubo, Hiroshi Tsujibo, Masafumi Ogawa, Yoshinobu Saito, Yasuyoshi Miki, Shoji Takemura

著者情報

キーワード: 3, 3'-dihydroxy-α, β-diethylstilbene, diethylstilbestrol, coralgil (diethylaminoethoxy hexestrol dihydrochloride), phospholipidosis, hormonal side effect, ichthyotoxicity, vasodilator action, 3, 3', 4, 5'-tetra-hydroxystilbene, 3, 4-O-isopropylidene-3, 3', 4

ジャーナルフリー

1987 年 35 巻 2 号 p. 887-890

DOI https://doi.org/10.1248/cpb.35.887

詳細

抄録

Like diethylstilbestrol (II), 3, 3'-dihydroxy-α, β-diethylstilbene (I), an isomer of II, had strong ichthyotoxicity and coronary vasodilator action on the isolated guinea-pig heart. The median tolerance limit (TLm) at 48 h was 3.00 ppm in Oryzias latipes and 3.20 ppm in Carassius auratus. The ichthyotoxic activity of I was stronger than that of II. The vasodilator activity of I in the isolated guinea-pig heart (ED₅₀ : 4.30 μg/ heart) was weaker than that of II (ED₅₀ : 0.26 μg/heart). However, the action of I was stronger than that of papaverine (ED₅₀ : 7.0 μg/heart), used as a standard. On the other hand, I, unlike II and other oxystilbene derivatives so far examined, had a cardiotonic effect. In this respect, the effect of I on the isolated guinea-pig heart is noteworthy. Owing to its negligible hormonal side effect, the above-mentioned activities of I are of considerable interest.

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