Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
THE SYNTHESIS OF LUPIN ALKALOIDS. I. TOTAL SYNTHESIS OF (±) -LEONTIFORMINE AND (±) -LEONTIFORMIDINE
Noriyuki Takatsu, Shigeru Ohmiya, Hirotaka Otomasu
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Keywords: lupin alkaloid, 3- (2'-piperidyl) quinolizidine, (±) -leontiformine, (±) -leontiformidine, 1, 3-dipolar cycloaddition, 1-piperine 1-oxide, 2
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1987 Volume 35 Issue 2 Pages 891-894

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Abstract
The novel total synthesis of the lupin alkaloids (±) -leontiformine (1) and (±) -leontiformidine (2) has been achieved by using the 1, 3-dipolar cycloaddition reaction of 1-piperine 1-oxide (4) twice in the synthesis process.
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© The Pharmaceutical Society of Japan
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