Amino Acids and Peptides. VIII. A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative

KOICHI KAWASAKI; TOSHIKI TSUJI; MITSUKO MAEDA; TATSUYA MATSUMOTO; KATSUHIKO HIRASE

doi:10.1248/cpb.35.1044

KOICHI KAWASAKI, TOSHIKI TSUJI, MITSUKO MAEDA, TATSUYA MATSUMOTO, KATSUHIKO HIRASE

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Keywords: water-soluble active ester, 2, 6-dichloro-4-sulfophenyl ester, 2, 6-dibromo-4- sulfophenyl ester, 2-nitro-4-sulfophenyl ester, peptide synthesis, Leu-enkephalin

JOURNAL FREE ACCESS

1987 Volume 35 Issue 3 Pages 1044-1048

DOI https://doi.org/10.1248/cpb.35.1044

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Abstract

N-Protected amino acid 4-phenolsulfonic acid derivative esters, such as 2, 6-dibromo-4- sulfophenyl ester sodium salt, 2, 6-dichloro-4-sulfophenyl ester potassium salt and 2-nitro-4- sulfophenyl ester sodium salt, were prepared. These esters are water-soluble active esters, and were applied for the synthesis of Leu-enkephalin.

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