Syntheses of 24, 25-Dihydroxyvitamin D2, 24, 25-Dihydroxy-22-dehydrovitamin D3, 25-Hydroxy-24-oxo-22-dehydrovitamin D3 and 22, 24, 25-Trihydroxyvitamin D3

KOTOMI KATSUMI; TOSHIO OKANO; YURIE ONO; EMIKO MAEGAKI; KUMIKO NISHIMURA; MIZUE BABA; TADASHI KOBAYASHI; OKIKO MIYATA; TAKEAKI NAITO; ICHIYA NINOMIYA

doi:10.1248/cpb.35.970

Syntheses of 24, 25-Dihydroxyvitamin D₂, 24, 25-Dihydroxy-22-dehydrovitamin D₃, 25-Hydroxy-24-oxo-22-dehydrovitamin D₃ and 22, 24, 25-Trihydroxyvitamin D₃

KOTOMI KATSUMI, TOSHIO OKANO, YURIE ONO, EMIKO MAEGAKI, KUMIKO NISHIMURA, MIZUE BABA, TADASHI KOBAYASHI, OKIKO MIYATA, TAKEAKI NAITO, ICHIYA NINOMIYA

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Keywords: 24, 25-dihydroxyvitamin D₂, 24, 25-dihydroxy-22-dehydrovitamin D₃, 25-hy-droxy-24-oxo-22-dehydrovitamin D₃, 22, 24, 25-trihydroxyvitamin D₃, vitamin D, ergosterol, highperformance liquid chromatography

JOURNAL FREE ACCESS

1987 Volume 35 Issue 3 Pages 970-979

DOI https://doi.org/10.1248/cpb.35.970

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Abstract

Four vitamin D₂ and D₃ metabolites, 24, 25-dihydroxyvitamin D₂ (8), 24, 25-dihydroxy-22-dehydrovitamin D₃ (10). 25-hydroxy-24-oxo-22-dehydrovitamin D₃ (12) and 22, 24, 25-trihydroxy-vitamin D₃ (14), were synthesized from ergosterol (1) via the hydroxyketone (4) as a common key intermediate.

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