Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A CONVENIENT AND EFFICIENT METALLATION OF METHYLSILANE. CARBONYL METHYLENATIONS USING METALLATED (2-AMINOALKOXY)TRIMETHYLSILANE
Akira Hosomi, Shinya Kohra, Yoshinori Tominaga, Masataka Shoji, Hideki Sakurai
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Keywords: lithiated methylsilane, α-silyl carbanion, (2-aminoalkoxy) trimethylsilane, Peterson reaction, alkene synthesis
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1987 Volume 35 Issue 4 Pages 1663-1665

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Abstract
When (2-aminoalkoxy) trimethylsilane is activated by two intramolecular heteroatoms (oxygen and nitrogen), it undergoes metallation efficiently with t-butyllithium to yield α-silyl carbanion. This process is applicable to carbonyl methylenations.
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© The Pharmaceutical Society of Japan
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