Occurrence of Marinobufotoxin and Telocinobufotoxin Homologs in the Skin of Bufo bankorensis BORBOUR

Abstract

The occurrence of marinobufagin 3-succinyl-L-arginine and 3-glutaryl-L-arginine esters, and telocinobufagin 3-glutaryl-L-arginine ester, together with seven known bufogenins, in the skin of Bufo bankorensis BORBOUR, is reported. The structures were elucidated by degradative means and/or direct comparison with authentic samples. These compounds were assayed for inhibitory activity towards guinea pig heart Na⁺, K⁺-adenosine triphosphatase.