Synthesis and Oral Absorption of Hetacillin and Hetamoxicillin Labile Esters

SANTIAGO GUBERT; CELIA PALACIN; AURELIO SACRISTÁN; JOSÉ A. ORTIZ

doi:10.1248/cpb.35.2366

SANTIAGO GUBERT, CELIA PALACIN, AURELIO SACRISTÁN, JOSÉ A. ORTIZ

著者情報

キーワード: oxyhetacillin ester, hetacillin ester, benzyloxymethyl ester, prodrug, oral absorption, plasma level

ジャーナルフリー

1987 年 35 巻 6 号 p. 2366-2372

DOI https://doi.org/10.1248/cpb.35.2366

詳細

抄録

Nine esters of hetacillin or hetamoxicillin were synthesized as ampicillin and amoxicillin derivatives with the aim of obtaining improved plasma levels after oral administration. Out of these esters, which are devoid of apparent toxic effects, the benzyloxymethyl ester of hetacillin (FI-5204) gave the best result and was chosen for subsequent studies.

責任著者(Corresponding author)

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