ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP

抄録

Fluoroalkyl alkynyl ketones (1a-c) were reduced enantioselectively by (R) -BINAL-H and (S) -Alpine-Borane to give optically active alcohols (2a-c). In the BINAL-H reduction, the trifluoromethyl group exerted an electronic effect on the enantioselectivity of the reagent.